2 edition of Studies on the disposition and testicular toxicity of di-(2-ethylhexyl) phthalate found in the catalog.
Studies on the disposition and testicular toxicity of di-(2-ethylhexyl) phthalate
Series of papers combined to form a thesis for the Department of Anatomy and Histology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala.
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Structure activity studies with a range of phthalate monoesters showed good agreement between the induction of germ cell detachment in culture and testicular toxicity in vivo. Three metabolites of MEHP (metabolites V, VI, and IX) were much less toxic in culture than MEHP itself, suggesting that the latter may be the active testicular toxin from. The aim of this study was to examine the effects of epigallocatechinO-gallate (EGCG) on hepatic damage and testicular toxicity in male mice exposed to daily oral administration of di-(2-ethylhexyl) phthalate (DEHP). A mouse model was used to assess the effects of daily intraperitoneal EGCG injection on hepatic and testicular damage.
Progress 01/01/99 to 12/31/99 Outputs This project is investigating metabolic mechanisms of testicular and epididymal toxicity caused by environmental chemicals. In studies with the rice herbicide molinate recent work has provided further evidence that a molinate metabolite generated via sulfoxidation is responsible for testicular toxicity. This book considers these possibilities, providing an authoritative summary of knowledge. Reversibility in Testicular Toxicity Assessment is organized by testicular element and will provide an important reference source for toxicology researchers and reproductive medicine clinicians involved with reproductive toxicity.
Dose levels may be based on information from acute toxicity tests or on results from repeated dose studies. If a vehicle is used in administering the test chemical, the control group should receive the vehicle in the highest volume used. Dose levels should be selected taking into account any existing toxicity and (toxico-) kinetic data. This study is the first to provide direct evidence that phthalates have the ability to suppress human testicular steroidogenesis, and notably androgen synthesis. Previous studies have failed to provide evidence of any direct anti-androgenic effect of either MBP (Hallmark et al., ) or MEHP (Lambrot et al., ) in human fetal testis.
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Studies evaluating testicular toxicity. III. NONCLINICAL EVALUATION. Introduction Nonclinical evaluation of the male reproductive system is a standard component of the.
Background: Detection of chemically induced effects on male fertility and on testicular spermatogenesis in particular, has become of increasing concern. More stringent regulatory guidelines, introduced by ICH, EPA and OECD (Table 1) have raised the awareness of toxicologists and pathologists for the need to conduct sensitive and careful evaluation of the male reproductive tract for potential Cited by: The Food and Drug Administration (FDA or Agency) is announcing the availability of a final guidance for industry entitled “Testicular Toxicity: Evaluation During Drug Development.”.
In vitro studies addressed the hallmarks of the BA testicular toxicity: the mild hormone effect, the initial IS, and atrophy. No effect of BA on the steroidogenic function of isolated Leydig cells was observed, supporting the contention of a CNS-mediated rather than a direct hormone by: The present study was designed to test the hypothesis that the testicular toxicity of DEHP is mediated by a decrease in Zn levels, possibly due to altered expression of ZnT To simulate human chronic exposure to DEHP better than the single dose model, a model in which rats were administered DEHP repeatedly at regular intervals (albeit, high Cited by: REVIEW ARTICLE Evaluation of Testicular Toxicity in Safety Evaluation Studies: The Appropriate Use of Spermatogenic Staging* DIANNE M.
CREASY Huntingdon Life Sciences, Eye, Suffolk IP23 7PX. Abstract. In a day toxicity study in rats, di-(2-ethylhexyl)phthalate (DEHP) produced testicular atrophy. To characterise further the testicular toxicity of phthalate esters the effect of age on the induction of testicular atrophy has been examined as well as the reversibility of the lesions and the effects of certain other phthalate esters.
This study aimed to integrate and analyze the existing studies and to explore research trends and hotspots related to the effects of xenobiotics on glucose metabolism in male testes.
All articles were retrieved from the PubMed database, from an inception date up to 10 June toxicity study is a key feature in the assessment of the safety of chemicals.
One may distinguish be-tween its use for the predictive evaluation of new compounds and its incorporation in a scheme de-signed to helplessen orclarify arecognized hazard.
It is required that these studies becarried outin two species, a rodent and a nonrodent. Animal. Diethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal care products.
DEHP is noncovalently bound to plastics, and therefore, it will leach out of these products after repeated use, heating, and/or cleaning of the products. Due to the overuse of DEHP in many products, it enters and. The Toxicology of Glycol Ethers and its Relevance to Man ECETOC TR No.
95 Measurement methods 56 Health effects 59 Haematological effects 60 Behavioural and neurological effects 62 Reproductive effects 63 Other effects, including poisoning 67 Occupational exposure limit values Toxicology Letters, 11 () Eisevier Biomical Press SPECIES DIFFERENCES IN THE TESTICULAR TOXICITY OF PHTHALATE ESTERS T.J.B.
GRAY, I.R. ROWLAND, P.M.D. FOSTER and S.D. GANGOLLI British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS (U.K.) (Received November 17th, ) (Accepted December 1st, ) SUMMARY Oral administration of di. Testicular toxicity accounts for about 50% of infertility cases in men.
Though, there are several approaches to detect the toxicity, the histopathological study of alterations occurred in the seminiferous tubules appear to be the most accepted, sensitive and direct marker of testicular toxicity.
Application of testicular sperm head counts in the assessment of male reproductive toxicity. In: Methods in Toxicology, Vol. 3, Pt. Male Reproductive Toxicology, RE Chapin and JJ Heindel (eds). Academic Press, San Diego, California, pp. 86 - Toxicity Report Series Number NTP Technical Report on Toxicity Studies of.
Dibutyl Phthalate (CAS No. ) Administered in Feed to F/N Rats and B6C3F. Mice. Daniel S. Marsman, D.V.M., Ph.D., Study Scientist National Toxicology Program Post Office Box Research Triangle Park, NC NIH Publication March CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Phthalate esters are ubiquitous, low-level environmental con-taminants that induce testicular toxicity in laboratory animals.
The diester is rapidly metabolized in the gut to the monoester, which causes the testicular toxicity.
Several physiologically based pharmacokinetic (PBPK) model structures have been evaluated. Data were abstracted from records of toxicity studies performed at the Huntingdon Research Centre during the years A sample of dogs aged between 37 weeks and years was analysed.
Testicular toxicity accounts for about 50 % of infertility cases in men. Though, there are several approaches to detect the testicular toxicity, the histopathological study of alterations occurred in the seminiferous tubules appear to be most accepted, sensitive and direct marker of toxicity.
However, an appropriate understanding of the process of spermatogenesis and its hormonal regulation is. Testicular Toxicity Study Design in the Clinical Stage. The FDA has highlighted the following outcomes in nonclinical trials, that would increase the likelihood of testicular toxicity monitoring in the clinical phase protocols: Findings occur at clinically relevant exposures or small multiples of the clinical exposure.
Differentiating between Testicular Toxicity and Sexual Immaturity in Ortho-phthalaldehyde Inhalation Toxicity Studies in Rats and Mice Natasha R. Catlin1,2, Cynthia J. Willson3, Dianne M. Creasy4, Deepa B. Rao3,5, Grace E. Kissling1, Barry S. McIntyre1, and Michael Wyde1 Abstract. 74 initiating follow-up studies evaluating testicular toxicity.
3. 75 76 III. NONCLINICAL EVALUATION. 78 A. Introduction. 80 81 Nonclinical evaluation of the male reproductive system is a standard component of the 82 nonclinical safety assessment during .METHODS OF STUDY. In Vivo Study of Testicular Microvasculature.
In Vivo Study of Extratesticular Microvasculature. Animal Models for Blood Vessel Toxicity Studies. In Vitro Methods for the Study of Testicular and Extratesticular Microvasculature. TOXIC AGENTS AFFECTING TESTICULAR VASCULATURE. Lead. Cobalt. Cadmium. STUDIES OF TESTICULAR.
Gray TJ and Gangoilli. Aspects of the testicular toxicity of phthalate n Health Perspect March Swan SH, Main KM, Liu F, Stewart SL, Kruse RL, Calafat AM, et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure.
Environ Health Perspect –; doi: